Thomas Carlstedt

I graduated from the Karolinska Institute in Stockholm in 1979 with a basic medical degree - MD and a research degree-PhD. Following a "post doc" year in Montreal I returned to the Karolinska Institute to become an Assistant Professor. After completing surgical training in Stockholm and Paris, I specialised in Nerve and Plexus surgery, I was made an Associate Professor of Surgery in 1988 and then Head of the Division of Neuro-Orthopaedics at the Karolinska Hospital. I founded a Swedish National Centre for complicated nerve injuries.

I was recruited as a Consultant Orthopaedic Nerve Surgeon to the Royal National Orthopaedic Hospital, Stanmore in London 1996. I was awarded a visiting Professorship at Imperial College of Science, Technology and Medicine in 2002 and 2003 a Professorship in Nerve Surgery from University College London. In 2006 I became a Professor of Hand Surgery at the Karolinska Institute.

I have 20 years of experience as a consultant. I am a leading and internationally renowned surgeon and basic scientist that has pioneered and developed surgical treatments of complicated nerve disorders such as brachial and lumbosacral plexus . I treat severe,complicated nerve lesions and conditions.

Activity

My main activities include nerve and plexus trauma, tumours as well as entrapment disorders of nerves. I also do hand surgery.

I direct a National Centre for the surgical treatment of complicated nerve injuries including nerve plexus and associated spinal cord injuries.

I have devoted the last 30 years to basic and clinical researches to solve and develop successful methods to repair spinal cord injuries associated with nerve plexus trauma.

I am an active member of the Clinical Research Initiative supported by Spinal research

I have produced 12 Chapters in books, 9 Review articles and 73 peer review articles in international highly rated clinical and basic science journals. I have written one book on a surgical technique that restores function after a type of spinal cord injury. I am a reviewer for several international scientific journals.

Publications (last 5 years)

Carlstedt, T. (2002)Overcoming PNS-CNS boundaries. Clinical approaches. In Glia interfaces (eds Aldskogius, H Fraher. K) l OS Press, Amsterdam. 71-75.

S. Cullheim,W.Wallquist, H.Hammarberg, H.Lindå, F.Piehl, T.Carlstedt, M.Risling (2002)Properties of motoneurons underlying their regenerative capacity after lesions in the ventral funiculus or at the surface of the spinal cord. Review. Brain Res. Reviews.40,309-316

T. Lindholm, S. Cullheim,M. Deckner,T.Carlstedt,M.Risling(2002). Expression of neurogulin and ErbB3 and ErbB4 after a traumatic lesion in the ventral funiculus of the spinal cord and in the intact primary olfactory system. Exp.Brain Res.142, 81-90.

T. Lindholm, S.Cullheim,T. Carlstedt,M.Risling(2002)Expression of tenascinR and J1 mRNA in motoneurons after a traumatic lesion in the spinal cord. Neuroreport,12, 3513-3517

R.G.Hallin, T.Carlstedt, G.Wu (2002) Population of human cutaneous mechanoreceptive units. Behav. Brain Res. 20,135,19-26.

W.Wallquist, M.Patarroyo, S.Thams, T.Carlstedt, B.Stark, S.Cullheim, H. Hammarberg (2002)Laminin chains in rat and human peripheral nerve: Distribution and regulation during development and after axonal injury. J.Comp.Neurol.16, 454, 284-293,

Birch R.and Carlstedt T. (2003) Management of Peripheral Nerve Injuries. In Youmans Neurological Surgery IV. Eds Winn R.et al.W.B. Saunders.3967-3988.

Carlstedt T. Cullheim S. Risling M.(2003) Spinal Cord in Relation to the Peripheral Nervous System.In, The Human Nervous System ll. Eds Paxinos G,. Mai J. Academic Press.250-263.

M.Landry,K.Åman, J.Dostrovsky,A.M. Lozano, T.Carlstedt, C.Spenger, A.Josephson ,Z.Wiesenfeld-Hallin and T.Hökfelt (2003).Galanin expression in adult human dorsal root ganglion neurons:initial observations. Neuroscience,117/4,795-809.

Morgenstern DA, Asher RA, Naidu M, Carlstedt T, Levine JM, Fawcett JW (2003). Expression and glycanation of the NG2 proteoglycan in developing,adult and damaged peripheral nerve .Mol Cell Neurosci 24, 787-802.

T.Lindholm, MK Skold, A Suneson T Carlstedt, S Cullheim, M Risling (2004). Semaphorin and neuropilin expression in motoneurons after intraspinal motoneuron axotomy. NeuroReport 15,649-654.

A Bergerot, PJ Shortland, P Anand, SP Hunt,T Carlstedt (2004).Co-treatment with riluzole and GDNF is necessary for functional recovery after ventral root avulsion injury. Experimental Neurology 187,359-366.

T Carlstedt,P Anand, M Htut, P Misra, M Svensson.(2004). Restoration of hand function and "breathing arm" from spinal cord repair of C5-T1 brachial plexus avulsion injury.Case Report. Neurosurgical Focus 16 (5)Article 7.

E Lang, J Borges, T Carlstedt (2004).Surgical treatments of lumbosacral plexus injuries.Journal of Neurosurgery:Spine(1),1,64-71.

Li Ying, T Carlstedt, C-H Berthold, G Raisman (2004).Interaction of olfactory ensheathing cells and host astrocytic processes provides a bridge for axons to regenerate across the dorsal root entry zone.Experimental Neurology, 188,300-308.

B Blits, T Carlstedt, M Ruitenberg, F de Winter, TMJC Hermens, P Dijkhuizen, J Claasens, R Eggers, R van der Sluis L Tenenbaum, G Boer, J Verhaagen (2004). Rescue and sprouting of motoneurons following ventral root avulsion and reimplantation combined with intraspinal adenoassociated viral vector-mediated expression of glial cell line derived neurotrophic factor or brain derived nerotrophic factor. Experimental Neurology 189/2,303-316.

Birch R and Carlstedt T(2005). Musculotendinous unit transfer after nerve injury. In,tendon Transfers in Reconstructive Hand Surgery.Ed J. Friden. Taylor and Francis pp51-68.

Carlstedt, T. (2006)Surgical management of spinal nerve root injuries. In; Operative Neurosurgical Techniques. Ed.Schmidek, H.H. Saunders. 5th edition, pp 2265-2274.

T Carlstedt.(2006) Mechanisms behind closed brachial plexus injuries. Clinical Risk 12, 16-17.

N.Kato, M. Thut, M.Taggart,T.Carlstedt,R.Birch (2006). The effects of operative delay on the relief of neuropathic pain after injury to the brachial plexus. A review of 148 cases. Journal of Bone and Joint Surgery (Br.) 88-b,756-759.

M.Htut,VP Misra, P Anand, R Birch,T Carlstedt.(2006) Pain phenomena and sensory recovery following brachial plexus avulsion injury and surgical repairs. Journal of Hand Surgery. 31,596-605.

K. Mannan, T Carlstedt.(2006) Injuries to the brachial plexus. Surgery, 24, 12, 409-414.

Invited talks (last 5 years)

2002

Karolinska Institutet,Stockholm,Sweden.

2003

Workshop for Neurosurgeons. May 26-27. Surgery of the Brachial Plexus and Peripheral nerves.
Stockholm, Sweden Continental Surgeons' Course R.N.O.H.
Invited lecture and patient demonstrations, June 19.
Seddon Society, Invited lecture June 20. R.N.O.H.
Royal Society of Medicine, London. June 27.Invited lecture "What's New in Neurological Emergencies".

2004

Chirurgie de la Main. Le Present du Future.March 19,Paris. Invited lecture."Reimplantation de racines arrachees.
Advances in Peripheral Nerve Surgery and Regeneration. Brussels April 2.Invited lecture "Intraspinal repair".

Continental Surgeons Course, R.N.O.H., June 11,Seminar and demonstrations of patients.
Spinal Research Network Meeting, ISRT, London Sept.4.Restoration of spinal cord circuitry and function after nerve root injury in humans.

Royal College of Surgeons of England. Advanced Skill Course in Hand Surgery, Nov8-11,Faculty Member.
Guy's Hospital.Invited lecture "Brachial Plexus Injuries: Assessement, Repair and Reconstruction."

2005

Shimonoseke, Japan. The 28th Peripheral Nerve Conference. "Restoration of function after re-implantation of avulsed roots into the spinal cord" Invited lecture. April 22
Lisbon, Portugal. Vertebral column and Spinal Cord Repair May 20,21,2005.Invited lecture.
Göteborg,Sweden. Tendon transfers, FESSH Xth meeting June 16.
Perugia, Italy. Trauma, diagnosis and treatment of complicated nerve injuries in conjunction with sports and orthopaedic injuries. June 27.

2006

San Francisco, U.S.A.. 74th Annual Meeting of the American Association of Neurological Surgeons (AANS).Key Note Lecture. "Nerve Root Reimplantation: Past, Present and Future. April 26.